Identification of Regulatory T Cells via the Global Gene Regulator Satb1

Simple SummaryContent extracted from patent full text and abstract with AI.

This invention describes a new method for identifying regulatory T cells (Treg) by utilizing the low or absent presence of the protein SATB1 within these cells. By applying specific ligands, such as antibodies that bind to SATB1, researchers and clinicians can distinguish Treg from other T cell types based on reduced binding to these ligands. The invention also offers kits or diagnostic compositions to perform this identification, enhancing the quality control of T cell populations.

Use CasesContent extracted from patent full text and abstract with AI.

• Quality control of regulatory T cell populations in clinical cell therapies (e.g., for autoimmune diseases, transplant tolerance).
• Detection and quantification of regulatory T cells in blood samples for diagnostic purposes.
• Assessment of Treg purity during laboratory cell isolation and expansion for research or therapeutic applications.
• Detection of contaminating effector T cells within Treg preparations, and vice versa, to ensure accurate immunological experiments or safe cell therapies.
• Identification and monitoring of immune status in patients with cancer, autoimmunity, or immune system dysregulation.
• Basic immunological research to study T cell development, stability, and lineage commitment.

BenefitsContent extracted from patent full text and abstract with AI.

• Provides a highly specific and sensitive method to distinguish regulatory T cells from other T cell types based on the unique expression pattern of SATB1.
• Enables improved quality control and standardization of Treg cell preparations for research and therapeutic use, reducing risks of contamination with unwanted effector cells.
• Can be adapted into a kit or diagnostic tool for simple and widespread use in clinical or research laboratories.
• Supports monitoring of immune therapies' effectiveness and safety by allowing precise measurement of Treg populations.
• Improves understanding of T cell biology and plasticity, aiding the development of new immunotherapies.

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Inventors & Applicants

Patent Abstract

The present invention provides a method for the identification of regulatory T cells based on the diminished abundance or even absence of the global gene regulator SATB1 in such regulatory T cells. In particular, the invention relates to a method utilizing ligands that specifically bind to SATB1 for identifying regulatory T cells which are cells showing a reduced binding to said ligand. Such method is suitable for quality determination of a regulatory T cell population. The invention further provides a kit or diagnostic composition for such method.