Liquisolid Pharmaceutical Formulation and Process for Manufacturing

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This invention provides a liquisolid pharmaceutical formulation and a manufacturing process for it, designed to improve the oral bioavailability of poorly water-soluble drugs. The core idea is to disperse the drug in propylene carbonate (or a similar solvent), then load this mixture onto porous carrier particles like mesoporous silica. This creates a powder-like product that can be easily processed into solid dosage forms (such as tablets or capsules), resulting in faster and more effective drug absorption when ingested.

Use CasesContent extracted from patent full text and abstract with AI.

• Development of oral solid dosage forms (tablets, capsules) for poorly water-soluble medications.
• Enhancing the effectiveness of existing drugs with low aqueous solubility by reformulating them using this liquisolid technique.
• Improving personalized medicine and flexible dosing for drugs with solubility-related absorption challenges.
• Facilitating pharmaceutical R&D and clinical studies involving compounds previously limited by poor oral bioavailability.
• Production of more cost-effective and reliable generic medications with improved performance.

BenefitsContent extracted from patent full text and abstract with AI.

• Significantly improves the dissolution and absorption rates of drugs that normally have poor water solubility.
• Enables faster onset of drug action compared to traditional formulations, providing rapid therapeutic effects.
• Reduces required drug dosage by increasing bioavailability, which can lower side effects and material costs.
• Uses non-toxic, low-viscosity solvents (like propylene carbonate) suitable for pharmaceutical manufacturing.
• Allows the use of standard, existing pharmaceutical processing equipment, reducing manufacturing complexity and costs.
• Results in free-flowing, easy-to-formulate powders suitable for large-scale production.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The present invention relates to a liquisolid pharmaceutical formulation comprising a porous carrier and an active pharmaceutical ingredient loaded onto a surface of the porous carrier, wherein the active pharmaceutical ingredient is dispersed in propylene carbonate or a mixture of propylene carbonate and a further solvent and the dispersion of the active pharmaceutical ingredient and propylene carbonate or a mixture of propylene carbonate and a further solvent is loaded onto the external surface and the internal surface located inside the pores of the porous carrier thereby forming a liquisolid system, and to a process for manufacturing such a liquisolid pharmaceutical formulation.